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Article

Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.

Human molecular genetics - 15 Sept 2007

Valenza Marta, Carroll Jeffrey B, Leoni Valerio, Bertram Lisa N, Björkhem Ingeman, Singaraja Roshni R, Di Donato Stefano, Lutjohann Dieter, Hayden Michael R, Cattaneo Elena

Abstract excerpt

Our recent analyses of the cholesterol biosynthetic pathway in Huntington's disease (HD) cells, in the R6/2 huntingtin-fragment mouse model of HD as well as in human tissues have provided the first evidence of altered activity of this pathway in genetically identifiable HD samples. Here we report...

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Identifiers

PMID: 17613541
DOI: 10.1093/hmg/ddm170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17613541-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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