Article
HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation.
PloS one - 1 Jan 2015
Carroll Jeffrey B, Deik Amy, Fossale Elisa, Weston Rory M, Guide Jolene R, Arjomand Jamshid, Kwak Seung, Clish Clary B, MacDonald Marcy E
Abstract excerpt
The HTT CAG expansion mutation causes Huntington's Disease and is associated with a wide range of cellular consequences, including altered metabolism. The mutant allele is expressed widely, in all tissues, but the striatum and cortex are especially vulnerable to its effects. To more fully understand this tissue-specificity, early in the disease process, we asked whether the metabolic impact of the mutant CAG...
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