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Article

Screening of Therapeutic Strategies for Huntington's Disease in YAC128 Transgenic Mice

16 Feb 2011

Abstract excerpt

Huntington’s disease (HD) is a hereditary neurodegenerative disorder caused by an unstable expansion of cytosine-adenine-guanine (CAG) repeats in the HD gene. The symptoms include cognitive dysfunction and severe motor impairment with loss of voluntary movement coordination that is later replaced by bradykinesia and rigidity. The neuropathology is characterized by neuronal loss mainly in the striatum and cortex,...

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PMID: 21501423
DOI: 10.1111/j.1755-5949.2011.00246.x

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