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Article

A genetic screen for zebrafish mutants with hepatic steatosis identifies a locus required for larval growth.

Journal of anatomy - 1 Mar 2017

Hugo Sarah E, Schlegel Amnon

Abstract excerpt

In a screen for zebrafish larval mutants with excessive liver lipid accumulation (hepatic steatosis), we identified harvest moon (hmn). Cytoplasmic lipid droplets, surrounded by multivesicular structures and mitochondria whose cristae appeared swollen, are seen in hmn mutant hepatocytes. Whole body triacylglycerol is increased in hmn mutant larvae. When we attempted to raise mutants, which were morphologically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27976367
DOI: 10.1111/joa.12570
PMCID: PMC5314394

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