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Article

GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling.

The Biochemical journal - 1 Sept 2015

Stretton Clare, Hoffmann Thorsten M, Munson Michael J, Prescott Alan, Taylor Peter M, Ganley Ian G, Hundal Harinder S

Abstract excerpt

The mammalian or mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a ubiquitously expressed multimeric protein kinase complex that integrates nutrient and growth factor signals for the co-ordinated regulation of cellular metabolism and cell growth. Herein, we demonstrate that suppressing the cellular activity of glycogen synthase kinase-3 (GSK3), by use of pharmacological inhibitors or shRNA-mediated...

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Source

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Identifiers

PMID: 26348909
DOI: 10.1042/BJ20150404
PMCID: PMC4652938

Genes

ULK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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