Article
Proline-rich Akt substrate of 40-kDa contains a nuclear export signal.
Cellular signalling - 1 Sept 2013
Wiza Claudia, Nascimento Emmani B M, Linssen Margot M L, Carlotti Françoise, Herzfeld de Wiza Daniella, van der Zon Gerard C M, Maassen J Antonie, Diamant Michaela, Guigas Bruno, Ouwens D Margriet
Abstract excerpt
The proline-rich Akt substrate of 40-kDa (PRAS40) has been linked to the regulation of the activity of the mammalian target of rapamycin complex 1 as well as insulin action. Despite these cytosolic functions, PRAS40 was originally identified as nuclear phosphoprotein in Hela cells. This study aimed to detail mechanisms and consequences of the nucleocytosolic trafficking of PRAS40. Sequence analysis identified a...
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