Detecting clusters of mutations.

Abstract excerpt

Positive selection for protein function can lead to multiple mutations within a small stretch of DNA, i.e., to a cluster of mutations. Recently, Wagner proposed a method to detect such mutation clusters. His method, however, did not take into account that residues with high solvent accessibility are inherently more variable than residues with low solvent accessibility. Here, we propose a new algorithm to detect...

Topics

• Algorithms
• Amino Acid Sequence
• Animals
• Cluster Analysis
• DNA
• Escherichia coli
• Genome
• Humans
• Models, Genetic
• Molecular Conformation
• Molecular Sequence Data
• Mutation
• Proteins
• Sequence Homology, Amino Acid
• Solvents