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Comparative mutational profiles of the environmental mammary carcinogen, 6-nitrochrysene and its metabolites in a lacI mammary epithelial cell line.

Carcinogenesis - 1 Nov 2007

Guttenplan Joseph B, Zhao Zhong-lin, Kosinska Wieslawa, Norman Robert G, Krzeminski Jacek, Sun Yuan-Wan, Amin Shantu, El-Bayoumy Karam

Abstract excerpt

The dietary and environmental agent, 6-nitrochrysene (6-NC) is a powerful mammary carcinogen and mutagen in rats. It is known to be metabolized by ring-oxidation, nitro-reduction and a combination of the two pathways. In order to determine the ultimate mutagenic metabolites, we have compared the previously determined mutational profile of 6-NC in rat mammary gland [T. Boyiri, et al. (2004) Carcinogenesis, 25,...

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PMID: 17602172
DOI: 10.1093/carcin/bgm142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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