Article
Congenitally osteosclerotic (os/os) rabbits are not cured by bone marrow transplantation from normal littermates.
The American journal of anatomy - 1 Nov 1991
Popoff S N, Marks S C
Abstract excerpt
The osteopetrotic (os) rabbit is a lethal mutation of autosomal recessive inheritance characterized by hypocalcemia, hypophosphatemia, fibrosis of marrow spaces, and ultrastructural abnormalities in both osteoclasts and osteoblasts. Procedures involving the transplantation of cells from normal hemopoietic tissues, which are sources of osteoclast precursors, are known to cure osteopetrosis in several mutations...
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