Is the osteopetrotic (op/op mutant) mouse completely deficient in expression of macrophage colony-stimulating factor?

doi:10.1089/jir.1995.15.279

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Article

Is the osteopetrotic (op/op mutant) mouse completely deficient in expression of macrophage colony-stimulating factor?

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Apr 1995

Hume D A, Favot P

Abstract excerpt

The op/op mouse has a mutation in the macrophage colony-stimulating (CSF-1) gene. The phenotype of gross deficiency in the macrophage and osteoclast lineages corrects significantly with age, suggesting that other factors can substitute for CSF-1. This review examines the evidence that the op/op m...

Topics

Aging
Animals
Cell Differentiation
Cell Division
Gene Expression Regulation
Humans
Macrophage Colony-Stimulating Factor
Mice
Mice, Mutant Strains
Osteopetrosis
Phenotype

Source

Open in PubMed

Identifiers

PMID: 7627801
DOI: 10.1089/jir.1995.15.279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7627801-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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