Article
Colony-stimulating factor 1 when combined with parathyroid hormone or 1,25-dihydroxyvitamin D can produce osteoclasts in cultured neonatal metatarsals from toothless (tl-osteopetrotic) rats.
Bone - 1 Apr 1995
Peura S R, Marks S C
Abstract excerpt
Toothless (tl-osteopetrotic) rats have little or no endogenous bone resorption, no marrow spaces, and very few osteoclasts and macrophages, and their live metatarsal rudiments cannot support the development of normal osteoclasts in vitro. The recent demonstration that exogenous colony-stimulating...
Topics
- Animals
- Animals, Newborn
- Bone Marrow Cells
- Dihydroxycholecalciferols
- Macrophage Colony-Stimulating Factor
- Metatarsal Bones
- Mice
- Mutation
- Organ Culture Techniques
- Osteoclasts
- Osteopetrosis
- Parathyroid Hormone
- Rats
- Spleen