Article
Interdependence of skeletal sclerosis and elevated circulating levels of 1,25-dihydroxyvitamin D in osteopetrotic (op and tl) rats.
Bone - 1 Jan 2000
Popoff S N, Osier L K, Zerwekh J E, Marks S C
Abstract excerpt
Osteopetrosis describes a heterogeneous group of inherited, metabolic bone disorders characterized by reduced bone resorption which coexists with elevated circulating levels of 1,25-dihydroxyvitamin D [1,25(OH)2D]. To determine whether or not skeletal sclerosis and high concentrations of 1,25(OH)2D are interdependent, this study used two distinct, nonallelic osteopetrotic mutations in the rat, osteopetrosis (op)...
Topics
- Analysis of Variance
- Animals
- Bone Resorption
- Bone and Bones
- Calcitriol
- Cell Count
- Cell Survival
- Disease Models, Animal
- Hindlimb
- Macrophage Colony-Stimulating Factor
- Mutation