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Article

Abnormalities in bone cell function and endochondral ossification in the osteopetrotic toothless rat.

Bone - 1 Oct 1996

Seifert M F

Abstract excerpt

The toothless (tl) rat is an osteopetrotic mutation whose excess skeletal mass is produced by a defect in its skeletal microenvironment. Its skeletal sclerosis fails to be cured by bone marrow transplantation but is largely reversed by exogenous administration of colony stimulating factor 1 which increases osteoclast neogenesis and resorptive activity. Recent studies have also indicated abnormalities in growth...

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Identifiers

PMID: 8894138
DOI: 10.1016/s8756-3282(96)00220-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abnormalities in bone cell function and endochondral ossification in the osteopetrotic toothless rat.PMID 8894138Read ↗

Lack of evidence for rickets in the osteopetrotic rat mutation, toothless.Semantic proximity Read ↗

Colony-stimulating factor 1 when combined with parathyroid hormone or 1,25-dihydroxyvitamin D can produce osteoclasts in cultured neonatal metatarsals from toothless (tl-osteopetrotic) rats.Semantic proximity Read ↗

Mineral density and bone strength are dissociated in long bones of rat osteopetrotic mutations.Semantic proximity Read ↗

The effects of colony-stimulating factor-1 (CSF-1) on the development of osteoclasts and their expression of tartrate-resistant acid phosphatase (TRAP) in toothless (tl-osteopetrotic) rats.Semantic proximity Read ↗

Interdependence of skeletal sclerosis and elevated circulating levels of 1,25-dihydroxyvitamin D in osteopetrotic (op and tl) rats.Semantic proximity Read ↗

Advances in osteoclast biology resulting from the study of osteopetrotic mutations.Semantic proximity Read ↗

Lessons from osteopetrotic mutations in animals: impact on our current understanding of osteoclast biology.Semantic proximity Read ↗

Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer.Semantic proximity Read ↗

The osteopetrotic mutation toothless ( tl ) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossificationSemantic proximity Read ↗

Administration of colony stimulating factor-1 corrects some macrophage, dental, and skeletal defects in an osteopetrotic mutation (toothless, tl) in the ratSemantic proximity Read ↗

Bone metabolism in the osteopetrotic rat mutation microphthalmia blanc.Semantic proximity Read ↗

A new osteopetrosis mutant mouse strain (ntl) with odontoma-like proliferations and lack of tooth roots.Semantic proximity Read ↗

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