Article
Post-weaning high-fat diet accelerates kidney injury, but not hypertension programmed by maternal diabetes.
Pediatric research - 1 Mar 2016
Aliou Yessoufou, Liao Min-Chun, Zhao Xin-Ping, Chang Shiao-Ying, Chenier Isabelle, Ingelfinger Julie R, Zhang Shao-Ling
Abstract excerpt
BACKGROUND: The aim of this study was to establish the underlying mechanisms by which a post-weaning high-fat diet (HFD) accelerates the perinatal programming of kidney injury occurring in the offspring of diabetic mothers. METHODS: Male mice, offspring of nondiabetic and diabetic dams were fed with normal diet (ND) or HFD from 4 to 20 wk of age. Rat renal proximal tubular cells were used in vitro. RESULTS: On...
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