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Article

Lipid peroxidation regulates podocyte migration and cytoskeletal structure through redox sensitive RhoA signaling.

Redox biology - 1 Jun 2018

Kruger Claudia, Burke Susan J, Collier J Jason, Nguyen Trang-Tiffany, Salbaum J Michael, Stadler Krisztian

Abstract excerpt

Early podocyte loss is characteristic of chronic kidney diseases (CKD) in obesity and diabetes. Since treatments for hyperglycemia and hypertension do not prevent podocyte loss, there must be additional factors causing podocyte depletion. The role of oxidative stress has been implicated in CKD but it is not known how exactly free radicals affect podocyte physiology. To assess this relationship, we investigated...

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Identifiers

PMID: 29547847
DOI: 10.1016/j.redox.2018.02.024
PMCID: PMC5854917

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