Article
Increased glomerular filtration rate in early metabolic syndrome is associated with renal adiposity and microvascular proliferation.
American journal of physiology. Renal physiology - 1 Nov 2011
Li Zilun, Woollard John R, Wang Shenming, Korsmo Michael J, Ebrahimi Behzad, Grande Joseph P, Textor Stephen C, Lerman Amir, Lerman Lilach O
Abstract excerpt
Metabolic syndrome (MetS) is associated with glomerular hyperfiltration and is a risk factor for chronic kidney disease, but the underlying mechanisms are poorly defined. This study tested the hypothesis that increased glomerular filtration rate (GFR) in early MetS is associated with renal adiposity and microvascular proliferation. Twelve MetS-prone Ossabaw pigs were randomized to 10 wk of a standard (lean, n =...
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