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Article

Mutation of delta-sarcoglycan is associated with Ca(2+) -dependent vascular remodeling in the Syrian hamster.

The American journal of pathology - 1 Jul 2007

Lipskaia Larissa, Pinet Caroline, Fromes Yves, Hatem Stéphane, Cantaloube Isabelle, Coulombe Alain, Lompré Anne-Marie

Abstract excerpt

We examined whether mutation of the delta-sarcoglycan gene, which causes dilated cardiomyopathy, also alters the vascular smooth muscle cell (VSMC) phenotype and arterial function in the Syrian hamster CHF 147. Thoracic aorta media thickness showed marked variability in diseased hamsters with zones of atrophy and hypertrophied segments. CHF-147 VSMCs displayed a proliferating/"synthetic" phenotype characterized...

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Aorta, Thoracic
Calcium Channels
Cricetinae
Dystrophin
Mesocricetus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle, Smooth, Vascular

NFATC Transcription Factors

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Identifiers

PMID: 17591963
DOI: 10.2353/ajpath.2007.070054
PMCID: PMC1941595

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