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Article

Accelerated cardiac remodeling in desmoplakin transgenic mice in response to endurance exercise is associated with perturbed Wnt/β-catenin signaling.

American journal of physiology. Heart and circulatory physiology - 15 Jan 2016

Martherus Ruben, Jain Rahul, Takagi Ken, Mendsaikhan Uzmee, Turdi Subat, Osinska Hanna, James Jeanne F, Kramer Kristen, Purevjav Enkhsaikhan, Towbin Jeffrey A

Abstract excerpt

Arrhythmogenic ventricular cardiomyopathy (AVC) is a frequent underlying cause for arrhythmias and sudden cardiac death especially during intense exercise. The mechanisms involved remain largely unknown. The purpose of this study was to investigate how chronic endurance exercise contributes to desmoplakin (DSP) mutation-induced AVC pathogenesis. Transgenic mice with overexpression of desmoplakin, wild-type...

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Share to Arrhythmogenic Right Ventricular Dysplasia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26545710
DOI: 10.1152/ajpheart.00295.2015
PMCID: PMC4796627

Genes

DSP
AKT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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