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Article

Attenuation of Smooth Muscle Cell Phenotypic Switching by Angiotensin 1-7 Protects against Thoracic Aortic Aneurysm.

International journal of molecular sciences - 8 Dec 2022

Jadli Anshul S, Ballasy Noura N, Gomes Karina P, Mackay Cameron D A, Meechem Megan, Wijesuriya Tishani Methsala, Belke Darrell, Thompson Jennifer, Fedak Paul W M, Patel Vaibhav B

Abstract excerpt

Thoracic aortic aneurysm (TAA) involves extracellular matrix (ECM) remodeling of the aortic wall, leading to reduced biomechanical support with risk of aortic dissection and rupture. Activation of the renin-angiotensin system, and resultant angiotensin (Ang) II synthesis, is critically involved in the onset and progression of TAA. The current study investigated the effects of angiotensin (Ang) 1-7 on a murine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred C57BL

Share to Myocytes, Smooth Muscle

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Identifiers

PMID: 36555207
DOI: 10.3390/ijms232415566
PMCID: PMC9779869

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