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Article

The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate.

The Journal of cell biology - 2 Jul 2007

Vanderluit Jacqueline L, Wylie Crystal A, McClellan Kelly A, Ghanem Noel, Fortin Andre, Callaghan Steve, MacLaurin Jason G, Park David S, Slack Ruth S

Abstract excerpt

The Retinoblastoma protein p107 regulates the neural precursor pool in both the developing and adult brain. As p107-deficient mice exhibit enhanced levels of Hes1, we questioned whether p107 regulates neural precursor self-renewal through the repression of Hes1. p107 represses transcription at the Hes1 promoter. Despite an expanded neural precursor population, p107-null mice exhibit a striking reduction in the...

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Identifiers

PMID: 17591923
DOI: 10.1083/jcb.200703176
PMCID: PMC2064429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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