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Article

Compensation by tumor suppressor genes during retinal development in mice and humans

3 May 2006

Abstract excerpt

BACKGROUND: The RB1 gene was the first tumor suppressor gene cloned from humans by studying genetic lesions in families with retinoblastoma. Children who inherit one defective copy of the RB1 gene have an increased susceptibility to retinoblastoma. Several years after the identification of the human RB1 gene, a targeted deletion of Rb was generated in mice. Mice with one defective copy of the Rb gene do not...

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PMID: 16672052
DOI: 10.1186/1741-7007-4-14

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