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Article

The neurogenesis-controlling factor, Pax6, inhibits proliferation and promotes maturation in murine astrocytes.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Apr 2008

Sakurai Katsuyasu, Osumi Noriko

Abstract excerpt

Astrocytes serve various important functions in the CNS, but the molecular mechanisms of their generation and maturation are still enigmatic. Here, we show that Pax6, a key transcription factor that controls neurogenesis, also regulates proliferation, differentiation, and migration of astrocytes in the CNS. We first reveal that Pax6 is expressed in astrocytes during development as well as postnatally in the...

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Identifiers

PMID: 18448636
DOI: 10.1523/JNEUROSCI.5074-07.2008
PMCID: PMC6670447

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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