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Article

Effects of elevated Pax6 expression and genetic background on mouse eye development.

Investigative ophthalmology & visual science - 1 Sept 2009

Chanas Simon A, Collinson J Martin, Ramaesh Thaya, Dorà Natalie, Kleinjan Dirk A, Hill Robert E, West John D

Abstract excerpt

PURPOSE: To analyze the effects of Pax6 overexpression and its interaction with genetic background on eye development. METHODS: Histologic features of eyes from hemizygous PAX77(+/-) transgenic (high Pax6 gene dose) and wild-type mice were compared on different genetic backgrounds. Experimental PAX77(+/-)<-->wild-type and control wild-type<-->wild-type chimeras were analyzed to investigate the causes of abnormal...

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PMID: 19387074
DOI: 10.1167/iovs.07-1630
PMCID: PMC2763115

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