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Article

RAS/RAF pathway activation in gliomas: the result of copy number gains rather than activating mutations.

Acta neuropathologica - 1 Aug 2007

Jeuken Judith, van den Broecke Caroline, Gijsen Sabine, Boots-Sprenger Sandra, Wesseling Pieter

Abstract excerpt

Aberrant RAS/RAF signaling has been reported to be important for many tumor types including gliomas. Activation of the RAS/RAF pathway can result from oncogenic mutations of RAS/RAF itself. However, such mutations have only occasionally been reported in gliomas. In order to further elucidate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17588166
DOI: 10.1007/s00401-007-0239-0

Genes

BRAF
NRAS
EGF
HRAS
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17588166-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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