Article
Oncogenic activating mutations are associated with local copy gain.
Molecular cancer research : MCR - 1 Aug 2009
Modrek Barmak, Ge Lin, Pandita Ajay, Lin Eva, Mohan Sankar, Yue Peng, Guerrero Steve, Lin William M, Pham Thinh, Modrusan Zora, Seshagiri Somasekar, Stern Howard M, Waring Paul, Garraway Levi A, Chant John, Stokoe David, Cavet Guy
Abstract excerpt
Although activating mutations and gains in copy number are key mechanisms for oncogene activation, the relationship between the two is not well understood. In this study, we focused on KRAS copy gains and mutations in non-small cell lung cancer. We found that KRAS copy gains occur more frequently in tumors with KRAS activating mutations and are associated with large increases in KRAS expression. These copy gains...
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