Article
Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma.
Acta neuropathologica - 1 Jun 2011
Cin Huriye, Meyer Claus, Herr Ricarda, Janzarik Wibke G, Lambert Sally, Jones David T W, Jacob Karine, Benner Axel, Witt Hendrik, Remke Marc, Bender Sebastian, Falkenstein Fabian, Van Anh Ton Nu, Olbrich Heike, von Deimling Andreas, Pekrun Arnulf, Kulozik Andreas E, Gnekow Astrid, Scheurlen Wolfram, Witt Olaf, Omran Heymut, Jabado Nada, Collins V Peter, Brummer Tilman, Marschalek Rolf, Lichter Peter, Korshunov Andrey, Pfister Stefan M
Abstract excerpt
Activation of the MAPK signaling pathway has been shown to be a unifying molecular feature in pilocytic astrocytoma (PA). Genetically, tandem duplications at chromosome 7q34 resulting in KIAA1549-BRAF fusion genes constitute the most common mechanism identified to date. To elucidate alternative mechanisms of aberrant MAPK activation in PA, we screened 125 primary tumors for RAF fusion genes and mutations in KRAS,...
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