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BRAF Duplications and MAPK Pathway Activation Are Frequent in Gliomas of the Optic Nerve Proper

14 Aug 2012

Abstract excerpt

Optic pathway gliomas represent a specific subtype of astrocytoma with unique clinicopathologic and biologic properties, but studies of tumors in the optic nerve proper have been hampered by limited tissue availability. We analyzed optic nerve gliomas of 59 patients (median age, 9 years; range, 3 months-66 years; 33 female, 26 male) using formalin-fixed paraffin-embedded material in tissue microarrays. Seven...

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PMID: 22892521
DOI: 10.1097/nen.0b013e3182656ef8

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