BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas.

doi:10.1172/JCI33656

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Article

BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas.

The Journal of clinical investigation - 1 May 2008

Pfister Stefan, Janzarik Wibke G, Remke Marc, Ernst Aurélie, Werft Wiebke, Becker Natalia, Toedt Grischa, Wittmann Andrea, Kratz Christian, Olbrich Heike, Ahmadi Rezvan, Thieme Barbara, Joos Stefan, Radlwimmer Bernhard, Kulozik Andreas, Pietsch Torsten, Herold-Mende Christel, Gnekow Astrid, Reifenberger Guido, Korshunov Andrey, Scheurlen Wolfram, Omran Heymut, Lichter Peter

Abstract excerpt

The molecular pathogenesis of pediatric astrocytomas is still poorly understood. To further understand the genetic abnormalities associated with these tumors, we performed a genome-wide analysis of DNA copy number aberrations in pediatric low-grade astrocytomas by using array-based comparative genomic hybridization. Duplication of the BRAF protooncogene was the most frequent genomic aberration, and tumors with...

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Identifiers

PMID: 18398503
DOI: 10.1172/JCI33656
PMCID: PMC2289793

Genes

BRAF
CCND1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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