Fine mapping of disease genes using tagging SNPs.

doi:10.1111/j.1469-1809.2007.00379.x

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Article

Fine mapping of disease genes using tagging SNPs.

Annals of human genetics - 1 Nov 2007

Sjölander Arvid, Hössjer Ola, Hartman Linda Werner, Humphreys Keith

Abstract excerpt

We describe a haplotype clustering approach for localising a disease mutation within a fixed genomic region, which supplements tagging SNP (tSNP) information with (external) information on linkage disequilibrium. By applying our method to simulated data based on the coalescent, and on real haplot...

Topics

Algorithms
Bayes Theorem
Chromosome Mapping
Cluster Analysis
Computer Simulation
Genetic Markers
Genetic Predisposition to Disease
Genome, Human
Haplotypes
Humans
Linkage Disequilibrium
Models, Genetic
Mutation
Polymorphism, Single Nucleotide

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