Article
Fine mapping of disease genes via haplotype clustering.
Genetic epidemiology - 1 Feb 2006
Waldron E R B, Whittaker J C, Balding D J
Abstract excerpt
We propose an algorithm for analysing SNP-based population association studies, which is a development of that introduced by Molitor et al. [2003: Am J Hum Genet 73:1368-1384]. It uses clustering of haplotypes to overcome the major limitations of many current haplotype-based approaches. We define a between-haplotype score that is simple, yet appears to capture much of the information about evolutionary...
Topics
- Algorithms
- Alleles
- Chromosome Mapping
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Humans
- Markov Chains
- Models, Genetic
- Monte Carlo Method
- Mutation
- Polymorphism, Single Nucleotide
- Predictive Value of Tests