Controlling mutation: intervening in evolution as a therapeutic strategy.

Abstract excerpt

Mutation is the driving force behind many processes linked to human disease, including cancer, aging, and the evolution of drug resistance. Mutations have traditionally been considered the inevitable consequence of replicating large genomes with polymerases of finite fidelity. Observations over the past several decades, however, have led to a new perspective on the process of mutagenesis. It has become clear...

Topics

• Animals
• Bacterial Proteins
• Drug Resistance, Bacterial
• Escherichia coli
• Evolution, Molecular
• Humans
• Models, Biological
• Mutagenesis
• Mutation