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Article

Involvement of Escherichia coli DNA polymerase II in response to oxidative damage and adaptive mutation.

Journal of bacteriology - 1 Oct 1994

Escarceller M, Hicks J, Gudmundsson G, Trump G, Touati D, Lovett S, Foster P L, McEntee K, Goodman M F

Abstract excerpt

DNA polymerase II (Pol II) is regulated as part of the SOS response to DNA damage in Escherichia coli. We examined the participation of Pol II in the response to oxidative damage, adaptive mutation, and recombination. Cells lacking Pol II activity (polB delta 1 mutants) exhibited 5- to 10-fold-greater sensitivity to mode 1 killing by H2O2 compared with isogenic polB+ cells. Survival decreased by about 15-fold...

Topics

Adaptation, Physiological
DNA Damage
DNA Polymerase II
Escherichia coli
Genetic Variation
Hydrogen Peroxide
Mutagenesis
Oxidation-Reduction
Phenotype
Recombination, Genetic
SOS Response, Genetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Homology

Superoxide Dismutase

Source

Open in PubMed Open full text

Identifiers

PMID: 7928992
DOI: 10.1128/jb.176.20.6221-6228.1994
PMCID: PMC196962

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7928992-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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