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Article

The UCS family of myosin chaperones

1 Nov 2002

Abstract excerpt

The canonical UCS (UNC-45/Cro1/She4p) protein, Caenorhabditis elegans UNC-45, was one of the earliest molecules to be shown genetically to be necessary for sarcomere assembly. Genetic analyses of homologues in several fungal species indicate that the conserved UCS domain functionally interacts with conventional type II and unconventional type V myosins. In C. elegans and other invertebrate species, UNC-45 and its...

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Identifiers

PMID: 12356904
DOI: 10.1242/jcs.00107

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The UCS family of myosin chaperonesPMID 12356904Read ↗

The UNC-45 myosin chaperone: from worms to flies to vertebrates.Semantic proximity Read ↗

Unc-45 mutations in Caenorhabditis elegans implicate a CRO1/She4p-like domain in myosin assembly.Semantic proximity Read ↗

X-ray crystal structure of the UCS domain-containing UNC-45 myosin chaperone from Drosophila melanogaster.Semantic proximity Read ↗

Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin.Semantic proximity Read ↗

The UCS factor Steif/Unc-45b interacts with the heat shock protein Hsp90a during myofibrillogenesis.Semantic proximity Read ↗

The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafish.Semantic proximity Read ↗

The myosin-binding UCS domain but not the Hsp90-binding TPR domain of the UNC-45 chaperone is essential for function in Caenorhabditis elegans.Semantic proximity Read ↗

Pathogenic Variants in the Myosin Chaperone UNC-45B Cause Progressive Myopathy with Eccentric Cores.Semantic proximity Read ↗

Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans.Semantic proximity Read ↗

Mutational analysis of the structure and function of the chaperone domain of UNC-45BSemantic proximity Read ↗

The myosin chaperone UNC-45 has an important role in maintaining the structure and function of muscle sarcomeres during adult aging.Semantic proximity Read ↗

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