Article
Rough eye is a gain-of-function allele of amos that disrupts regulation of the proneural gene atonal during Drosophila retinal differentiation.
Genetics - 1 Feb 2002
Chanut Françoise, Woo Katherine, Pereira Shalini, Donohoe Terrence J, Chang Shang-Yu, Laverty Todd R, Jarman Andrew P, Heberlein Ulrike
Abstract excerpt
The regular organization of the ommatidial lattice in the Drosophila eye originates in the precise regulation of the proneural gene atonal (ato), which is responsible for the specification of the ommatidial founder cells R8. Here we show that Rough eye (Roi), a dominant mutation manifested by severe roughening of the adult eye surface, causes defects in ommatidial assembly and ommatidial spacing. The ommatidial...
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