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Article

Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease.

Human immunology - 1 Jul 2007

Lie Benedicte A, Viken Marte K, Akselsen Hanne E, Flåm Siri T, Pociot Flemming, Nerup Jørn, Kockum Ingrid, Cambon-Thomsen Anne, Thorsby Erik, Undlien Dag E

Abstract excerpt

We have previously mapped a separate type 1 diabetes (T1D) association in the extended MHC class I region, marked by D6S2223, on the DRB1*03-DQA1*0501-DQB1*0201 haplotype. The associated region encompasses a gene encoding a thymus-specific serine protease (PRSS16), presumably involved in positive selection of T cells or in T-cell regulation. Fourteen PRSS16 polymorphisms were genotyped in two steps using a total...

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Identifiers

PMID: 17584581
DOI: 10.1016/j.humimm.2007.03.009

Genes

PRSS16

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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