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Article

Prss16 is not required for T-cell development.

Molecular and cellular biology - 1 Jan 2005

Cheunsuk Saijai, Lian Zhe-Xiong, Yang Guo-Xiang, Gershwin M Eric, Gruen Jeffrey R, Bowlus Christopher L

Abstract excerpt

PRSS16 is a serine protease expressed exclusively in cortical thymic epithelial cells (cTEC) of the thymus, suggesting that it plays a role in the processing of peptide antigens during the positive selection of T cells. Moreover, the human PRSS16 gene is encoded in a region near the class I major histocompatibility complex (MHC) that has been linked to type 1 diabetes mellitus susceptibility. The mouse orthologue...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15632078
DOI: 10.1128/MCB.25.2.789-796.2005
PMCID: PMC543420

Genes

PRSS16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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