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Article

Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice.

The Journal of clinical investigation - 1 May 2011

Viret Christophe, Leung-Theung-Long Stéphane, Serre Laurent, Lamare Camille, Vignali Dario A A, Malissen Bernard, Carrier Alice, Guerder Sylvie

Abstract excerpt

Type 1 diabetes is a chronic autoimmune disease in which genetic predispositions affect the immune system, leading to a loss of T cell tolerance to β cells and consequent T cell-mediated destruction of insulin-producing islet cells. Genetic studies have suggested that PRSS16 is linked to a diabetes susceptibility locus of the extended HLA class I region in humans. PRSS16 encodes what we believe to be a novel...

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Share to CD4-Positive T-Lymphocytes
Share to Diabetes Mellitus, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to Islets of Langerhans

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Serine Endopeptidases

Share to Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 21505262
DOI: 10.1172/JCI43314
PMCID: PMC3083765

Genes

PRSS16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice.PMID 21505262Read ↗

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