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Article

Structure and evolutionary analysis of a non-biological ATP-binding protein.

Journal of molecular biology - 10 Aug 2007

Mansy Sheref S, Zhang Jinglei, Kümmerle Rainer, Nilsson Mikael, Chou James J, Szostak Jack W, Chaput John C

Abstract excerpt

We present a structural and functional analysis of the evolutionary optimization of a non-biological protein derived from a library of random amino acid sequences. A series of previously described in vitro selection experiments transformed a low-affinity ancestral sequence into a stably folded, high affinity ATP binding protein structure. While the evolutionarily optimized protein differs from its ancestral...

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Identifiers

PMID: 17583732
DOI: 10.1016/j.jmb.2007.05.062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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