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Article

Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization.

PloS one - 23 May 2007

Smith Matthew D, Rosenow Matthew A, Wang Meitian, Allen James P, Szostak Jack W, Chaput John C

Abstract excerpt

Phylogenetic profiling of amino acid substitution patterns in proteins has led many to conclude that most structural information is carried by interior core residues that are solvent inaccessible. This conclusion is based on the observation that buried residues generally tolerate only conserved s...

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Share to Adenosine Triphosphate
Share to Amino Acid Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17520026
DOI: 10.1371/journal.pone.0000467
PMCID: PMC1867856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17520026-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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