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Article

Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail.

Proceedings of the National Academy of Sciences of the United States of America - 1 May 2012

Dvir Hay, Shah Mehul, Girardi Enrico, Guo Lixia, Farquhar Marilyn G, Zajonc Dirk M

Abstract excerpt

Hypercholesterolemia, high serum cholesterol in the form of LDL, is a major risk factor for atherosclerosis. LDL is mostly degraded in the liver after its cellular internalization with the LDL receptor (LDLR). This clathrin-mediated endocytosis depends on the protein autosomal recessive hypercholesterolemia (ARH), which binds the LDLR cytoplasmic tail. Mutations in either the LDLR tail or in ARH lead to...

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Identifiers

PMID: 22509010
DOI: 10.1073/pnas.1114128109
PMCID: PMC3344954

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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