Article
BAFF antagonist attenuates the development of skin fibrosis in tight-skin mice.
The Journal of investigative dermatology - 1 Dec 2007
Matsushita Takashi, Fujimoto Manabu, Hasegawa Minoru, Matsushita Yukiyo, Komura Kazuhiro, Ogawa Fumihide, Watanabe Rei, Takehara Kazuhiko, Sato Shinichi
Abstract excerpt
The tight-skin (TSK/+) mouse, a genetic model for systemic sclerosis (SSc), develops cutaneous fibrosis and autoimmunity. Although immunological abnormalities have been demonstrated in TSK/+ mice, the roles of B-cell-activating factor belonging to the tumor necrosis factor family (BAFF), a potent B-cell survival factor, have not been investigated. Serum BAFF levels in TSK/+ mice were examined by ELISA. Newborn...
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