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Article

Identification of Optimal Mouse Models of Systemic Sclerosis by Interspecies Comparative Genomics

6 Mar 2016

Abstract excerpt

OBJECTIVE: Understanding the pathogenesis of systemic sclerosis (SSc) is confounded by considerable disease heterogeneity. Animal models of SSc that recapitulate distinct subsets of disease at the molecular level have not been delineated. We applied interspecies comparative analysis of genomic data from multiple mouse models of SSc and patients with SSc to determine which animal models best reflect the SSc...

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PMID: 26945694
DOI: 10.1002/art.39658

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