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Article

Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites.

Molecular microbiology - 1 Jul 2007

Hunt Paul, Afonso Ana, Creasey Alison, Culleton Richard, Sidhu Amar Bir Singh, Logan John, Valderramos Stephanie G, McNae Iain, Cheesman Sandra, do Rosario Virgilio, Carter Richard, Fidock David A, Cravo Pedro

Abstract excerpt

Artemisinin- and artesunate-resistant Plasmodium chabaudi mutants, AS-ART and AS-ATN, were previously selected from chloroquine-resistant clones AS-30CQ and AS-15CQ respectively. Now, a genetic cross between AS-ART and the artemisinin-sensitive clone AJ has been analysed by Linkage Group Selection. A genetic linkage group on chromosome 2 was selected under artemisinin treatment. Within this locus, we identified...

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Identifiers

PMID: 17581118
DOI: 10.1111/j.1365-2958.2007.05753.x
PMCID: PMC1974797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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