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Article

Mutation in the 26S proteasome regulatory subunit rpn2 gene in Plasmodium falciparum confers resistance to artemisinin.

Frontiers in cellular and infection microbiology - 1 Jan 2024

Gonçalves Adriana F, Lima-Pinheiro Ana, Teixeira Miguel, Cassiano Gustavo Capatti, Cravo Pedro, Ferreira Pedro E

Abstract excerpt

Introduction: Malaria parasites increasingly develop resistance to all drugs available in the market, hampering the goal of reducing malaria burden. Methods: Herein, we evaluated the impact of a single-nucleotide variant, E738K, present in the 26S proteasome regulatory subunit rpn2 gene, identified in Plasmodium chabaudi resistant parasites. Plasmids carrying a functional rpn2 interspecies chimeric gene with 5'...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38404287
DOI: 10.3389/fcimb.2024.1342856
PMCID: PMC10884193

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