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Article

Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation.

Blood - 1 Oct 2007

Ragab Ashraf, Séverin Sonia, Gratacap Marie-Pierre, Aguado Enrique, Malissen Marie, Jandrot-Perrus Martine, Malissen Bernard, Ragab-Thomas Jeannie, Payrastre Bernard

Abstract excerpt

Linker for activation of T cells (LAT) is an adaptor protein required for organization of the signaling machinery downstream of the platelet collagen receptor, the glycoprotein VI (GPVI). Here, we investigated the effect of LAT mutations on specific signaling pathways and on platelet functions in response to GPVI triggering by convulxin (Cvx). Using mice containing tyrosine to phenylalanine mutations of the...

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Source

Identifiers

PMID: 17579183
DOI: 10.1182/blood-2007-02-075432

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation.PMID 17579183Read ↗

Delineation of the region in the glycoprotein VI tail required for association with the Fc receptor gamma-chain.Semantic proximity Read ↗

Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.Semantic proximity Read ↗

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.Semantic proximity Read ↗

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.Semantic proximity Read ↗

Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development.Semantic proximity Read ↗

Mutation of the glycine residue preceding the sixth tyrosine of the LAT adaptor severely alters T cell development and activation.Semantic proximity Read ↗

Reciprocal Signaling by Integrin and Nonintegrin Receptors during Collagen Activation of PlateletsSemantic proximity Read ↗

Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.Semantic proximity Read ↗

Fc Rgamma -independent signaling by the platelet collagen receptor glycoprotein VI.Semantic proximity Read ↗

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.Semantic proximity Read ↗

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.Semantic proximity Read ↗

Distinct and overlapping functional roles of Src family kinases in mouse platelets.Semantic proximity Read ↗

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