Article
Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans.
Human molecular genetics - 1 May 2006
Kraemer Brian C, Burgess Jack K, Chen Jin H, Thomas James H, Schellenberg Gerard D
Abstract excerpt
Mutations in the gene encoding tau cause frontotemporal dementia with parkinsonism--chromosome 17 type (FTDP-17). In FTDP-17, Alzheimer's disease, and other tauopathies, aggregated hyper-phosphorylated tau forms the neurofibrillary tangles characteristic of these disorders. We previously reported a Caenorhabditis elegans model for tauopathies using human normal and FTDP-17 mutant tau as transgenes. Neuronal...
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