Article
Polymorphisms in canine ATP7B: candidate modifier of copper toxicosis in the Bedlington terrier.
Veterinary journal (London, England : 1997) - 1 Aug 2008
Coronado Veronica A, O'Neill Brian, Nanji Manoj, Cox Diane W
Abstract excerpt
A COMMD1(MURR1) deletion has been reported as the cause of copper toxicosis (CT) in Bedlington terriers. Recent studies identified Bedlington terriers with copper accumulation without homozygous COMMD1 deletions. Wilson disease in humans is a copper storage disorder similar to CT caused by mutations in ATP7B, and COMMD1 has been shown to interact with the ATP7B protein. ATP7B may act as a modifier in CT, allowing...
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