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Article

Copper toxicosis in non-COMMD1 Bedlington terriers is associated with metal transport gene ABCA12.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) - 1 May 2016

Haywood Susan, Boursnell Mike, Loughran Michael J, Trafford James, Isherwood Diana, Liu Xuan, Olohan Lisa, Carter Stuart D

Abstract excerpt

Wilson's disease, caused by a mutation in the ATP-ase 7B gene, is the only genetically characterised human disease with inhibition of biliary copper excretion and toxic copper accumulation in liver and occasionally brain. A similar copper toxicosis occurs in Bedlington terriers (CT) with liver damage only. Although CT has been associated with a defect in the COMMD1 gene (COMMD1 (del/del)), Bedlington terriers...

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Source

Identifiers

PMID: 27049130
DOI: 10.1016/j.jtemb.2016.01.015

Genes

COMMD1
ABCA12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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