Article
Canine models of copper toxicosis for understanding mammalian copper metabolism.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2012
Fieten Hille, Leegwater Peter A J, Watson Adrian L, Rothuizen Jan
Abstract excerpt
Hereditary forms of copper toxicosis exist in man and dogs. In man, Wilson's disease is the best studied disorder of copper overload, resulting from mutations in the gene coding for the copper transporter ATP7B. Forms of copper toxicosis for which no causal gene is known yet are recognized as well, often in young children. Although advances have been made in unraveling the genetic background of disorders of...
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