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Article

Evaluation of COMMD1 in copper toxicosis in Labrador retrievers and Dobermans.

Veterinary journal (London, England : 1997) - 1 Nov 2020

Wu Xiaoyan, Mandigers Paul J J, Fieten Hille, Leegwater Peter A

Abstract excerpt

Copper toxicosis is a major cause of hepatitis in dogs. We have shown that variants in ATP7A and ATP7B modulate hepatic copper levels in Labrador retrievers and Dobermans. However, these variants cannot fully explain the observed variation in hepatic copper levels in these dog breeds. Homozygous deletion of exon 2 of COMMD1 causes copper toxicosis in Bedlington terriers. We investigated the possible involvement...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33129558
DOI: 10.1016/j.tvjl.2020.105561

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